Journal of Personal Science: Molybdenum and Avoiding Sulfur Helped My IBS

by August Hurtel

I live in Shreveport, Louisiana and work in the interlibrary loans department at Shreve Memorial library. I am 39 years old.

I believe, due to experiences I will expand upon below, that excess sulfur compounds, especially sulfites, may contribute to and even cause irritable bowel syndrome (IBS). If you have IBS, you can try to verify this in a few ways.

1) Try molybdenum. I take Carlson Lab’s Moly-B 500 mcg tablets (one tablet/day).

2) Avoid foods and supplements high in sulfur.

3) If you have already purchased the services of 23&me or want to, you can look at this thread in the forums — “Reactions to food containing sulfites, sulfur dioxide, bisulfite, metabisulfite. SUOX gene” — and see if you have the same polymorphisms, though if you just do the first two, you’ll be able to guess.

The woman who started that thread at 23&me goes by the name Red Ringlets. She asked if anyone with four polymorphisms involved in sulfur processing experience reactions to sulfur compounds commonly added to foods as preservatives and/or for antibacterial purposes. I have three of these polymorphisms. I knew I was allergic to certain medicines, but I had not thought about the effect of sulfur coming from my food and supplements largely because I associated reactions to sulfur with hives and headaches.

Several years ago once the appetite suppression the Shangri-La diet kicked in, I adopted what most would consider a paleo template for my diet. This means I generally avoid grains, legumes, and dairy with caveats (like rice, now that I work out, and butter because it is animal fat and therefore good according to evolutionary thinking). Additionally a substantial amount of the meat that I buy comes from conventional sources.

Despite not being technically paleo, I enjoyed coffee, chocolate, and red wine, which are all high in sulfur. Sulfur is also added to various coconut products, shrimp, fish, dried fruit — many products a person trying to eat paleo might eat. I ate them. And I would have gastrointestinal distress that I could not explain despite getting leaner.

In the summer of 2013 after a few social functions that served grilled hamburgers, grilled shrimp, and other summer party foods a paleo dieter might think would be okay, I went to the emergency room. I had a serious pain where my appendix should be. Sometimes the pain would get worse after eating, and I would often get diarrhea. I thought I had appendicitis, but the doctors found nothing wrong. They took regular X-rays and did blood tests, and came back and said they found nothing. I got really angry about that, so they ordered a CT scan. The CT scan also showed nothing. They told me I had IBS because they had gone through a list of other things it might be and eliminated all of them.

When I went to the emergency room, I also inadvertently took with me a large amount of sulfur. I had a couple of 90% Lindt bars with me. My chocolate intake had risen during that time, too. I had stuff to do, places to go — and an excuse to treat chocolate like a food group.

I was aware, from reading on the internet, of FODMAPs, which are osmotic carbohydrates that draw water into the gut, causing gas, bloating, cramping and diarrhea. They seemed a likely culprit because these were the symptoms I experienced. Following a low FODMAP diet seemed to help, but not perfectly so.

There is some overlap between the two lists of foods to avoid (high sulfur and high FODMAP), so avoiding FODMAPs might have helped because it made me avoid sulfur. It also made it possible for me to have days where I didn’t eat any FODMAP foods but I would eat something like shrimp and then I’d have symptoms despite not eating any FODMAPs. So, looking back on it, I think of attending a wedding, eating nothing but shrimp, and drinking a little bit of red wine, and then having IBS problems and not understanding why because it doesn’t fit in well with the FODMAP story. I think FODMAPs are problematic in a gut that has already been compromised, but FODMAPs are not evolutionarily novel, and thus are unlikely to be the original cause of the problem.

Since it was summer and I just gotten through that ER experience, I stopped eating a lot of fruits, chocolate, wine, etc. One of the things that figures largely for me as a source of sulfur during this time though is shrimp. I kept thinking it was a safe food to eat, and didn’t realize until later it was a source of sulfur. Additionally, I was taking several supplements that contained sulfur: gelatin, biotin, glutathione, NAC, ALA, MSM. I had gotten into the habit of trying different supplements since 2010 because of a neuralgia that neither doctors nor dentists could explain. Though I was not taking all of them at once, I did supplement enough to assume I kept my sulfur level high throughout this time period.

I noticed the thread Red Ringlets posted at 23&me in August of 2013. In October I asked whether or not sulfur could cause a dehydrating effect. I asked this because I’ve noticed wine can take more water out of me than other drinks containing alcohol do. I didn’t get an answer to that question, but I began to explore some of the links people had put into the thread. I read through this site: www.learningtarget.com. I found the following page particularly helpful because it mentioned that molybdenum is a vital part of the sulfite oxidase enzyme: Vitamins and Supplements for Sulfite Problems.

I still had not made a connection between sulfur and irritable bowel syndrome, but I decided to supplement with fucoidan, which is a sulfated polysaccharide found in some seaweeds. I thought it would help my gut, but it caused diarrhea. It was as if I had decided to supplement with cholera. The effect was large and obvious enough for me to realize it was probably the supplement I had just taken. Once I accepted that, I put together what I had learned from the 23&me thread.

Now, in retrospect, I think fucoidan may have caused diarrhea for completely different reasons. I learned in my 23&me health report that I am norovirus resistant, and I have subsequently read that this has something to do with my ability (or inability) to make fucose. I can’t remember where I read this, but it made me think fucoidan could have destabilized my gut flora for reasons unrelated to its sulfur content.

Whatever the reason for the extreme reaction to fucoidan, I decided the beneficial reaction to molybdenum meant that I had a genetically limited capacity to deal with all the extra sulfur in my food and supplements. I threw out my high sulfur supplements and tried to stick to low sulfur foods. Within about two weeks I started having normal bowel movements. This was better than what I was achieving before the entire fucoidan fiasco. I had migrated to a diet of rice and fish which helped me approximate normalcy, but any time I tried to have any variety in my diet, I would run into problems. By avoiding sulfur, I was able to eat a larger variety of foods without incident.

Eventually I found if I was very careful, I could eat small amounts of high sulfur foods, but this is hit or miss because I can’t reliably gauge what the potential dose is, nor is it always clear whether a food has sulfur in it. I still supplement with molybdenum but I think the long term strategy here is both molybdenum and at least avoiding high sulfite foods because my genetics suggest it is doubtful I am going to be able to process as many sulfites as other people do regardless of how much molybdenum I have.

As I mentioned before, I think once the gut is compromised, many things become irritants. Removing excess sulfur has increased my health a lot, but I suspect I need to improve gut flora, and possibly heal some tissue damage. The doctors may not be able to see it, but I still have residual pain in the region where my appendix is.

11 Responses to “Journal of Personal Science: Molybdenum and Avoiding Sulfur Helped My IBS”

  1. August Says:

    “I read through this site: sulfite oxidase enzyme:”

    Originally was

    “I found the page below particularly helpful because it mentioned Molybdenum is a vital part of the sulfite oxidase enzyme”

    And it looks like this other link completely disappeared:

    http://www.learningtarget.com/nosulfites/>www.learningtarget.com

  2. JM Says:

    August, great example of using careful observation and personal science to diagnose and treat yourself – and I think it’s pretty obvious that traditional medicine would never have figured this out. And thanks for sharing, maybe this will help someone else who is having similar problems.

  3. August Says:

    Thanks JM.

    It looks like I need to correct my correction. The link is:
    http://www.learningtarget.com/nosulfites/

  4. dr j Says:

    Dear August,
    Thank you for taking the time to write about your inspiring detective work! Its is extremely valuable to be able to mull over your process in approach; i am starting on a Lynch Syndrome path.
    best
    john

  5. Steve Says:

    August:

    I just checked my 23&me data. My results are the exactly the same as Red Ringlets and yours: SUOX rs10876864 AA, rs705703 CC, i5000977 AA, i5000976 AA . That would finally explain why I get such intense headaches when I drink red wine.

  6. Seth Roberts Says:

    Sorry. It appeared correctly in the visual editor.

  7. JRM Says:

    I started supplementing with molybdenum after I did a hair minerals analysis test which showed very low levels of molybdenum. I felt better. 23andme said that I was a slow metabolizer of caffeine. Molybdenum is used in caffeine detoxification via xanthine oxidase. Supplementation helped reduce caffeine withdrawal symptoms the next day.
    The farmer who I buy almost all of my beef from commented that my hair test was similar to his soil minerals test. A different local farmer commented that her soil minerals test showed a deficiency in molybdenum. When I go to the farmer’s market, I find that asking farmers if they do soil mineral tests and supplementation is a good indicator of whether their food will taste good. The best farmers test beyond ph, Ca, Mg, N, P, K to a plethora of micronutrients Mo, Se, Fe, Cu, Zn, B, Mn, Cr, Co, etc. Soil mineral deficiencies become mineral deficiencies in the plants and animals grown on that soil. People can’t go to nutritiondata.com, plug in their daily diet, and assume that their diet contains all the necessary minerals because the website says it should.
    One of William Albrecht’s themes was that the soil quality in the South is compromised due to heat and precipitation leaching out the minerals from the soil. Maybe it is coincidence that the author is from the South. I don’t know.

    Other minerals which were low on the test like lithium (5 mg/day) and magnesium (via MgCl foot baths), I also noticed a benefit from supplementing. But I haven’t noticed a benefit from supplementing selenium.

  8. JRM Says:

    My markers are

    SUOX 56398711 i5000976 AA

    SUOX 56397916 i5000977 AA

    SUOX 56391486 rs705703 CC

    intergenic 56401085 rs10876864 AG

    I haven’t noticed a reaction to sulfites or sulfur containing foods.

  9. Louis Says:

    Hello, August,

    Thanks for writing this article. I imagine you might be helping many people; perhaps you’ve helped me at least. If nothing else, it’s another hypothesis for me to test.

    I believe I could have this issue with sulfites, so I’ve begun a low sulfur diet. I too have IBS that got slightly better on a low FODMAP diet, but by no means took care of it completely.

    I’m wondering a couple things:

    1. You say that you had normal BM’s after two weeks. Did that two week period include supplementing with molybdenum or was that on the low sulfite diet alone?
    2. I have a number of symptoms that I think are related to the IBS such as insomnia and difficulty concentrating. Did you too have symptoms related to your IBS? If so, did they go away or show improvement in two weeks too?

    Thanks!

  10. Anne Says:

    Hi August
    Thank you for taking the time to write down this post. It was really interesting, and I will try this out over the coming weeks. I will start today and take away MSM and instead put in some molyben.

    The last entry from Louis was really interesting and I am very intressted in your comments on that, because that is a big thing even for me.

    2. I have a number of symptoms that I think are related to the IBS such as insomnia and difficulty concentrating. Did you too have symptoms related to your IBS? If so, did they go away or show improvement in two weeks too?

    Kindly
    Anne

  11. August Says:

    Louis,

    The two week period included both molybdenum and the low sulfite diet.

    I can say I had problems sleeping at various times, but I had not associated it with I.B.S. because of stress in my life. I did not track my sleep during the two weeks and I can’t remember if it improved specifically during those two weeks.
    I have my windows covered and I try to avoid blue light at night, but I notice sleep changes depending on the season, stress, and I assume the more pain I am in, the more likely I will stay awake too, so I.B.S. must have had some effect.

    I can say I am sleeping reasonably well now. I wake up before my alarm, possibly in anticipation of the loud birds who inhabit my neighborhood.