Treatment of acne with isotretinoin is associated with suicide attempts, according to a new study. A puzzle is that suicide attempts started to rise before the treatment started. They sharply declined to baseline after treatment stopped.
Acne is an good target for self-experimentation because it is easy to measure and is surely related to diet. My discovery of the value of self-experimentation happened with acne: I discovered that of the two drugs my dermatologist had prescribed, one (benzoyl peroxide) worked, the other (tetracycline) didn’t. I had believed the opposite, that tetracycline worked and benzoyl peroxide didn’t work.