Seth's Blog

I am at a hotel. Yesterday I decided to take a walk. A short distance from the hotel I started to walk uphill. It was surprisingly hard. I realized I was sick.

I think this is what happens when your immune system is working properly: Sickness stops being obvious. I think my immune system is working well because I sleep well and eat plenty of fermented foods.

I have never heard sickness described like this by anyone else. I have heard it described in terms of obvious suffering thousands of times. Which suggests a lot of room for improvement.

A new study in the Annals of Internal Medicine asked how often placebo-controlled medical studies made clear what the placebo was. The abstract says:

Most studies did not disclose the composition of the study placebo.

Which may give the wrong impression. About 90% of the studies they looked at did not say what the placebo was.

The paper illustrates the problem with an example:

In one of these studies [where the placebo was not described], the authors commented that “The lack of any overall effect in patients with myocardial infarction might be related to the unexpectedly low mortality rate in the placebo group.” The possibility that the placebo composition may have influenced this “unexpectedly low mortality” was apparently not considered.

Thanks to Gunnar Schröder.

Someone asked Lydia Davis: Why another translation of Madame Bovary? She replied:

In the case of a book that appeared more than 150 years ago, like Madame Bovary, and that is an important landmark in the history of the novel, there is room for plenty of different English versions. For example, 1) the first editions of the original text may have been faulty, and over the years one or more corrected editions have been published, so that the earliest English translations no longer match the most accurate original; 2) the earliest translators (as was the case with the Muirs rendering Kafka) may have felt they needed to inflict subtle or not so subtle alterations on the style and even the content of the original so as to make it more acceptable to the Anglophone audience; with the passing of time, we come to deem this something of a betrayal and ask for a more faithful version. 3) Earlier versions may simply not be as good in other respects as they could be—let another translator have a try.

This reminds me of my three-part answer to the question a journalist asked me: why it mattered that butter improved my arithmetic speed by 5%.

Just as I disliked my answer, I disliked Davis’s answer. It’s hypothetical (“may have been faulty”, “may have felt”, “may not be as good as they could be”). It’s flat and obvious (earlier versions may have room for improvement). It’s irrelevant (bad translation of Kafka does not justify new translation of Flaubert).

I had trouble figuring out a better answer to what I was asked, but I could instantly say what Davis should have written: The story of how she decided to do a new translation. (“I began to think about doing a new translation when . . . “) That would have been a lot more emotion-laden and not hypothetical, obvious, or irrelevant.

As soon as I thought what Davis should have said, I could see what I should have said. I should have answered the journalist’s question like this: Why does 5% matter? Let me tell you why I was so excited by this. . . . 

Via Marginal Revolution.

I learned of The Human Factor: Inside the CIA’s Dysfunctional Intelligence Culture by Ishmael Jones (a pseudonym) from an interview on the New Yorker website. This comment by the author interested me:

Once the C.I.A. became a place to get rich, effective operations ended. Today, more than ninety per cent of C.I.A. employees live and work entirely within the United States, in violation of the C.I.A.’s founding charter [to supply only foreign intelligence].

I could say much the same about science: Once it became a place to get rich (or at least get large grants), effective science became a lot less common. A great deal of science is done by drug companies. They pay a lot. Some of their scientists are surely brilliant but their talents are wasted by the need to find solutions that will be highly profitable. My self-experimentation found solutions that cost nothing and make far more intellectual sense. I was able to do something that didn’t produce a lot of publications because it wasn’t my job.

Many skills make good full-time jobs. Science doesn’t. There is too much pressure for short-term results. Without short-term results, you may lose your job or your grant. (Or, in China, most of your income.) Nor is science a good source of status. If you want your science to provide your status, you will be under great pressure to conform. Yet for practically all scientists, it’s their full-time job and their main source of status. This may not make it impossible for them to do good work but I suspect it comes close to doing so. My self-experimentation was effective not only because it was fast and cheap (per experiment) but also because I could be slow (per publication) and do something low-status.

A few years ago, after I started taking about 3 tablespoons/day of flaxseed oil, my dentist told me my gums were much healthier. They were less red, more pink. Friends and blog readers who took flaxseed oil in similar amounts noticed the same thing. Tyler Cowen’s gums improved so much he no longer needed gum surgery.

An epidemiological study in the November Journal of the American Dietetic Association reports correlations between omega-3 intake and periodontitis (an extreme form of inflamed gums). The more omega-3, the less periodontitis. I’m sure that sufficient omega-3 intake cures periodontitis so this study has methodological interest for me. One interesting point is that the study reached a correct conclusion — contrary to the nihilism of John Ioannidis. Another is that the correlations were weak. The risk of periodontitis was only 20% lower in the group (quintile?) with the highest omega-3 intake. Although there were 9000 subjects, there was no significant correlation with linolenic acid, the form of omega-3 found in flaxseed oil.

Thanks to Sean Curley.