Archive for August, 2009

Not All Probiotics are Wonderful

Saturday, August 8th, 2009

From a mailing list I’m on:

Right before I left the U.S. I purchased Complete Probiotics from Dr. Mercola (online health guru). . . . I did not have the time needed to give these probiotics a good try before I left the States so I went ahead and purchased quite a bit. After arriving here in Beijing I began taking them just to find out they were not working well for me. I still think it is a good product, just not right for me.

I have 7 bottles total. 5 bottles expiration date: May 2011. 2 bottles expiration date: Dec. 2010

This batch I have has [in each capsule] 2 billion CFU [colony-forming units] and 500 mg of FOS [Fructooligosaccharides]. There are 90 V-caps per bottle. They are all completely sealed with shrink bands

Dr. Mercola’s sale price is $30 U.S.D. for a single bottle and about $25 U.S.D./each for a 3-pack. [the 3-pack costs $75]

She doesn’t say why they’re not right for her. I make kombucha for pennies per day. Homemade yogurt costs a few dimes per day. Also, they’re delicious, the kombucha is thirst-quenching, and the yogurt, as a condiment, improves many other dishes (salmon, soup, hamburger). So they’re easy to eat, whereas the vitamin pills I take I have to force myself to swallow. Because I am close to the making of the kombucha and yogurt — I sample them during brewing — I am sure that they have plenty of bacteria. With pills made in a factory, hard to be sure. And hard to know what those expiration dates mean.

Jane Jacobs and the Trouble with Medicine

Saturday, August 8th, 2009

In Slate, Barry Schwartz and Kenneth Sharpe argue convincingly that viewing bad performance as an “incentive problem” (meaning bad financial incentives) can be a mistake. If you pay doctors per procedure, they will do more procedures (too many); if you pay them per person, they will do fewer procedures (not enough). The heart of their argument is this:

When day care centers fine parents who are late to pick up their kids, lateness increases. Why? Because the fine turns a moral obligation (come on time!) into a service for a fee (we’ll take care of the kids if you pay us more!). Another example: When Swiss citizens were offered an incentive for agreeing to have a toxic waste dump in their community, their willingness to accept it fell by half. Why? The offer of an incentive induces them to ask What’s in my interest? instead of What are my responsibilities as a citizen? And when people offer a stranger a token payment for help unloading a couch from a moving van, strangers are less likely to agree than if offered nothing. Why? Because the offer of money has turned the assistance from a favor into a job.

So far so good. At this point the authors get lost. Here’s their advice about fixing medicine:

It is tempting, in light of our argument, to ask how can we incentivize good medical practice, so that we get more of it. Our answer is simple but perhaps unsatisfying: Good medical practice should be, and can be, its own reward. Almost all doctors want to practice good medicine—at least before they get socialized by the grind of medical school, residency, student debt, malpractice premiums, and the like.

The sign of their lostness is that they have zero data to back up this idea.

In Systems of Survival, Jane Jacobs argued that we can see around us two systems of morality: a guardian system, which stresses loyalty and hierarchy, and a commercial syndrome, which stresses honesty and equality. Each is internally consistent; but they are quite different, and those familiar with one system have a hard time understanding the other. She had plenty of data supporting her points. She went on to say that when the two systems are mixed — when policemen are given ticket quotas (= when policemen are treated like salesmen), for example — things go bad.

Why two systems? Because they correspond to two broad ways of making a living: taking and trading. The systems aren’t arbitrary; they have survived because they worked.

Are doctors takers or traders? The flaw in trying to improve doctor performance by changing incentives is the balance of power: Doctors have almost all of it. Patients trust doctors. (When I asked my surgeon the basis for her judgment that I needed surgery — treating her as an equal, in other words — she must have been stunned. She certainly didn’t respond appropriately.) That’s why it’s so easy for doctors to do too much or too little. It’s the same problem with quota systems for policemen: The policemen have too much power. The current balance of power makes doctors takers rather than traders.

So the choice is: either reduce the power of doctors relative to patients or give them moral training as guardians. The first isn’t going to happen in medical schools. Jacobs would recommend, I think, that doctors should be taught that they are guardians. (She might use the example of her father, who was a doctor.) And that those interested in improving medicine should study well-functioning guardian systems to see how they work or worked — how the accompanying moral system was instilled.

Probiotics Prevent Colds

Friday, August 7th, 2009

Here’s a summary of a study that just appeared in Pediatrics:

More than 300 children between three and five years of age were randomly assigned to receive three different milk formulations: plain milk, milk plus the bacterium Lactobacillus acidophilus, or milk with Lactobacillus plus the bacterium Bifodobacterium animalis.

The group that just received Lactobacillus were half as likely to develop a cold and a fever. They also had fewer coughs and runny noses. Those that got both strains of probiotics had 72 percent fewer fevers. They were also less likely to come down with a cough or runny nose. If they did get sick, they got better significantly sooner. They also missed fewer days of daycare.

Here’s the abstract of that study:

OBJECTIVE: Probiotic consumption effects on cold and influenza-like symptom incidence and duration were evaluated in healthy children during the winter season.

METHODS: In this double-blind, placebo-controlled study, 326 eligible children (3–5 years of age) were assigned randomly to receive placebo (N = 104), Lactobacillus acidophilus NCFM (N = 110), or L acidophilus NCFM in combination with Bifidobacterium animalis subsp lactis Bi-07 (N = 112). Children were treated twice daily for 6 months.

RESULTS: Relative to the placebo group, single and combination probiotics reduced fever incidence by 53.0% (P = .0085) and 72.7% (P = .0009), coughing incidence by 41.4% (P = .027) and 62.1% (P = .005), and rhinorrhea incidence by 28.2% (P = .68) and 58.8% (P = .03), respectively. Fever, coughing, and rhinorrhea duration was decreased significantly, relative to placebo, by 32% (single strain; P = .0023) and 48% (strain combination; P < .001). Antibiotic use incidence was reduced, relative to placebo, by 68.4% (single strain; P = .0002) and 84.2% (strain combination; P < .0001). Subjects receiving probiotic products had significant reductions in days absent from group child care, by 31.8% (single strain; P = .002) and 27.7% (strain combination; P < .001), compared with subjects receiving placebo treatment.

The probiotics were given as pills. Such large safe improvements are signs of a nutritional deficiency being remedied. It would be very hard to produce a drug that worked as well.

Thanks to Tom George.

Genius of Common Sense

Thursday, August 6th, 2009

From Genius of Common Sense, a new young-adult biography of Jane Jacobs by Glenna Lang and Marjory Wunsch, I learned that Jacobs was an independent-minded young girl:

When Jane’s third-grade teacher asked the class to raise their hands if they promised to brush their teeth every day for the rest of their lives, Jane refused to raise her hand and urged the other children not to raise theirs. . . Jane was expelled from school for the day.

Where have I read that before? In Chimamanda Adichie’s The Headstrong Historian:

Her teacher Sister Maureen told her that she could not refer to the call-and-response her grandmother had taught her as poetry, because primitive tribes did not have poetry. It was Grace who would laugh and laugh until Sister Maureen took her to detention.

Genius of Common Sense is plainly a labor of love, with a great selection of photographs and a belief in Jacobs’s importance that you might say “shines through the book like a watermark” (Nabokov).  The subtitle is “Jane Jacobs and the story of The Death and Life of Great American Cities” but that isn’t right: It’s mostly about how Jacobs and her neighbors fended off Robert Moses to preserve Greenwich Village. Which is a lot more visual. As I read it I kept wondering what I would have thought of it had I picked it up as, say, a third grader. I read a lot of biographies for children back then. I might have been attracted by the weird title and helped along by the high ratio (1 to 1) of picture space to word space. I would have liked the underdog aspect. Would I have appreciated the humor of

Several years later the Lower Manhattan Expressway was to raise its ugly head again. “The rule of thumb is that you have to kill expressways three times before they die,” Jane quipped.

? Probably not. But maybe I would have noticed how much the authors cared about their subject.

Sentence of the Day

Thursday, August 6th, 2009

Cafes are discouraging laptop use, says the WSJ:

At two of three Café Grumpy locations — one in Brooklyn and the other in Manhattan’s Chelsea neighborhood — laptops are never welcome.

But is this a change in policy?